Endocrine Abstracts

BackgroundHyponatremia is associated with increased risk of bone fragility and fractures. In vitro studies suggest a role of hyponatremia in stimulating osteoclast activation, whereas other studies rather revealed a possible role of acute hyponatremia in impairing osteoblast function. We aimed to assess whether and how correction of hyponatremia in hospitalized patients with the syndrome of inappropriate antidiuresis (SIAD) has an impact on bone...

Background: Differential diagnosis of hyponatremia is challenging, particularly for thiazide associated hyponatremia (TAH), as patients might have either volume depletion in need for fluid substitution or syndrome of inappropriate antidiuresis (SIAD)-like presentation requiring fluid restriction. Urine indices are of little utility, because they are influenced by thiazide therapy. Apparent strong ion difference (aSID) describes the relation between sodium, potassium and chlori...

Introduction: Hyponatremia is the most common electrolyte disorder encountered in clinical practice and is associated with increased mortality and morbidity, including an increased risk for osteoporosis and fragility fractures. Preclinical studies suggest osteoclast upregulation whereas a clinical study showed improved osteoblast fuction after hyponatremia normalization in hospitalized patients with SIAD.Methods: This is a secondary analysis of a double-...

Introduction: Onset of hyperkalemia has previously been reported during the administration of hypertonic resuscitation solutions. Since the hypertonic saline infusion test has recently been validated for the diagnosis of diabetes insipidus, we aimed to investigate the course of plasma potassium levels during the test.Material and Methods: Data of 144 patients undergoing osmotic stimulation with hypertonic saline infusion at 11 tertiary medical centres in...

Background: Hyponatremia is the most common electrolyte disorder in hospitalized patients with pneumonia. Different studies have shown an association of admission hyponatremia and worse in-hospital outcome, but no data are available about the impact of hyponatremia at discharge on outcome.Material and methods: Data from a double-blind randomized study including 725 patients hospitalized with community-acquired pneumonia were analyzed. The primary aim of ...

Introduction: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the predominant cause of hyponatremia but the available treatment options are unsatisfying and often of little efficiency. The selective sodium-glucose co-transporter 2 inhibitor empagliflozin promotes osmotic diuresis due to glucosuria and might be a novel treatment option for SIADH.Material and methods: From September 2016 through December 2018 we randomly assigned 88...